Pazopanib-13C,d3 (hydrochloride), CAS 1261398-44-0

Product Description: Pazopanib-13C,d3 (hydrochloride) is the deuterium and 13C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].

Applications: Cancer-Kinase/protease

Formula: C20 13CH21D3ClN7O2S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Harris PA, et al. Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51(15), 4632-4640./[3]Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov82(3):346-50.

CAS Number: 1261398-44-0

Molecular Weight: 477.99

Compound Purity: 97.51

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Autophagy;c-Fms;c-Kit;FGFR;PDGFR;VEGFR

• Artikelnummer: MEXHY-12009S-2.5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-12009S-2.5
• Green Labware: Nein
• Verpackungseinheit: 2.5 mg
• Mengeneinheit: STK