Pazopanib-d6, CAS 1219592-01-4

Product Description: Pazopanib-d6 is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

Formula: C21H17D6N7O2S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Harris PA, et al. Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51(15), 4632-4640./[3]Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82(3):346-50.

CAS Number: 1219592-01-4

Molecular Weight: 443.55

Compound Purity: 98.0

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Autophagy;c-Kit;FGFR;Isotope-Labeled Compounds;PDGFR;VEGFR

• Artikelnummer: MEXHY-10208S-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10208S-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK