Pretomanid-d5

Product Description: Pretomanid-d5 is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

Applications: COVID-19-immunoregulation

Formula: C14H7D5F3N3O5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Stover CK, et al. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature. 2000 Jun 22;405(6789):962-6./[3]Lenaerts AJ, et al. Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob Agents Chemother. 2005 Jun;49(6):2294-301./[4]Manjunatha UH, et al. Mycobacterium leprae is naturally resistant to PA-824. Antimicrob Agents Chemother. 2006 Oct;50(10):3350-4.

Molecular Weight: 364.29

Research Area: Cancer; Infection

Solubility: 10 mM in DMSO

Target: Antibiotic;Bacterial;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-10844S1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10844S1-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK