Pyrazinamide-13C,15N

Product Description: Pyrazinamide-13C,15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

Applications: COVID-19-immunoregulation

Formula: C4 13CH5N2 15NO

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Y Zhang, et al. Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol. 1999 Apr;181(7):2044-9./[3]Ying Zhang, et al. Mechanisms of Pyrazinamide Action and Resistance. Microbiol Spectr. 2014 Aug;2(4):MGM2-0023-2013.

Molecular Weight: 125.10

Research Area: Infection

Solubility: 10 mM in DMSO

Target: Antibiotic;Autophagy;Bacterial;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B0271S1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0271S1-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK