Quetiapine-d4-1 (fumarate), CAS 2820085-77-4

Product Description: Quetiapine-d4-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

Applications: Neuroscience-Neuromodulation

Formula: C21H21D4N3O2S.1/2C4H4O4

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66./[3]Hanzhi Wang, et al. Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination. Front Cell Neurosci. 2015 Dec 21;9:492.

CAS Number: 2820085-77-4

Molecular Weight: 445.57

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: 5-HT Receptor;Dopamine Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B0031S5-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0031S5-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK