(Rac)-Nebivolol-d2,15N

Product Description: (Rac)-Nebivolol-d2,15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C22H23D2F2 15NO4

References: [1]do Vale GT, et al. Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity. Cardiovasc Toxicol. 2021 Mar;21(3):224-235./[2]Cockcroft JR, et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharmacol Exp Ther. 1995 Sep;274(3):1067-71./[3]Oelze M, et al. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension. 2006 Oct;48(4):677-84./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 408.44

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Adrenergic Receptor;Isotope-Labeled Compounds;NADPH Oxidase

• Artikelnummer: MEXHY-B0203BS2-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0203BS2-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK