Raltegravir-d6, CAS 1100750-98-8

Product Description: Raltegravir-d6 is a deuterated labeled Raltegravir[1]. Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.

Formula: C20H15D6FN6O5

References: [1]Hare S, et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol. 2011 Oct;80(4):565-72./[2]Hare, S., et al., Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A, 2010. 107(46): p. 20057-62./[3]Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692./[4]Hicks C, et al. Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis. 2009 Apr 1;48(7):931-9/[5]Lewis, M.G., et al. Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy. Retrovirology, 2010. 7: p. 21./[6]Moss DM, et al. Divalent metals and pH alter raltegravir disposition in vitro. Antimicrob Agents Chemother. 2012 Jun;56(6):3020-6/[7]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

CAS Number: 1100750-98-8

Molecular Weight: 450.45

Research Area: Infection

Target: HIV;HIV Integrase;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-10353S1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10353S1-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK