Ramipril-d4, CAS 1132661-83-6

Product Description: Ramipril-d4 is deuterated labeled Ramipril (HY-B0279). Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.

Applications: Cancer-programmed cell death

Formula: C23H28D4N2O5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Raasch, W., et al., Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens, 2004. 22(3): p. 611-8./[3]Stevens, B.R., M.I. Phillips, and A. Fernandez, Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C, 1988. 91(2): p. 493-7./[4]Kohlstedt, K., et al., Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res, 2004. 94(1): p. 60-7./[5]Ceconi, C., et al., Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovasc Drugs Ther, 2007. 21(6): p. 423-9.

CAS Number: 1132661-83-6

Molecular Weight: 420.54

Research Area: Cancer; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Angiotensin-converting Enzyme (ACE);Apoptosis;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B0279S2-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0279S2-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK