Regorafénib N-oxyde (M2)-13C,d3, CAS 2140317-01-5

Product Description: Regorafénib N-oxyde (M2)-13C,d3 is the 13C- and deuterium labeled Regorafénib N-oxyde (M2). Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

Applications: Cancer-programmed cell death

Formula: C20 13CH12D3ClF4N4O4

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223./[2]Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.

CAS Number: 2140317-01-5

Molecular Weight: 502.83

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Drug Metabolite

• Artikelnummer: MEXHY-I0678S1-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-I0678S1-1
• Green Labware: Nein
• Verpackungseinheit: 1mg
• Mengeneinheit: STK