Ribociclib-d8, CAS 2167898-24-8

Product Description: Ribociclib-d8 is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2].

Applications: Cancer-Kinase/protease

Formula: C23H22D8N8O

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10./[3]Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 1519(22):6173-82.

CAS Number: 2167898-24-8

Molecular Weight: 442.59

Compound Purity: 99.23

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)

Target: CDK

• Artikelnummer: MEXHY-15777S1-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15777S1-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK