Rupatadine-d6 (D-tartrate)

Product Description: Rupatadine-d6 (D-tartrate) is deuterated labeled Rupatadine (HY-13511). Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C30H26D6ClN3O6

References: [1]Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21./[2]Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631./[3]Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 572.08

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Autophagy;Histamine Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-13511S-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-13511S-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK