Sorafenib-13C,d3, CAS 1210608-86-8

Product Description: Sorafenib-13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

Formula: C20 13CH13D3ClF3N4O3

References: [1]Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109./[2]El-Ashmawy NE, et al. Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor. Clin Exp Med. 2016 Apr 16./[3]Jin W, et al. Long non-coding RNA TUC338 is functionally involved in sorafenib-sensitized hepatocarcinoma cells by targeting RASAL1. Oncol Rep. 2017 Jan;37(1):273-280./[4]Li M, et al. Activation of an AKT/FOXM1/STMN1 pathway drives resistance to tyrosine kinase inhibitors in lung cancer. Br J Cancer. 2017 Aug 29./[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number: 1210608-86-8

Molecular Weight: 468.84

Compound Purity: 98.35

Research Area: Cancer

Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Apoptosis;Autophagy;Ferroptosis;FLT3;Raf;VEGFR

• Artikelnummer: MEXHY-10201S2-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10201S2-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK