Tadalafil-13C2,d3

Product Description: Tadalafil-13C2,d3 is 13C and deuterated labeled Tadalafil (HY-90009A). Tadalafil (IC-351) is a PDE5 inhibitor with an IC50 value of 1.8 nM.

Applications: Cancer-programmed cell death

Formula: C21 13C2H17D3N2O4

References: [1]Blount MA, et al. Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency,specificity, heterogeneity, and cGMP stimulation. Mol Pharmacol. 2004 Jul;66(1):144-52./[2]Yang Y, et al. Effect of acute tadalafil on sperm motility and acrosome reaction: in vitro and in vivo studies. Andrologia. 2013 Apr 14. [Epub ahead of print]/[3]Mostafa ME, et al. Effect of Chronic Low-dose Tadalafil on Penile Cavernous Tissues in Diabetic Rats. Urology. 2013 Jun;81(6):1253-60./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 393.42

Research Area: Cancer; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Apoptosis;Isotope-Labeled Compounds;Phosphodiesterase (PDE)

• Artikelnummer: MEXHY-90009AS-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-90009AS-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK