Talazoparib-13C,d4

Product Description: Talazoparib-13C,d4 is 13C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.

Formula: C18 13CH10D4F2N6O

References: [1]Wang B, et al. Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent. J Med Chem. 2016 Jan 14;59(1):335-57./[2]Shen Y, et al. BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.Clin Cancer Res. 2013 Sep 15;19(18):5003-15./[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 385.37

Compound Purity: 99.30

Research Area: Others

Solubility: DMSO : 25 mg/mL (ultrasonic;warming)

Target: Isotope-Labeled Compounds

• Artikelnummer: MEXHY-16106S-100UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-16106S-100UG
• Green Labware: Nein
• Verpackungseinheit: 100 μg
• Mengeneinheit: STK