Tasquinimod-d3, CAS 1416701-99-9

Product Description: Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor[1][2][3].

Applications: Cancer-programmed cell death

Formula: C20H14D3F3N2O4

References: [1]Isaacs JT, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013 Feb 15;73(4):1386-99./[2]Olsson A, et al. Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010 May 17;9:107./[3]Isaacs JT, et al. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment. Oncotarget. 2014 Sep 30;5(18):8093-106.

CAS Number: 1416701-99-9

Molecular Weight: 409.37

Compound Purity: 99.34

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: HDAC;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-10528S-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10528S-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK