Tempo-d18, CAS 205679-68-1

Product Description: Tempo-d18 is the deuterium labeled Tempo[1]. Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[2][3][4][5].

Applications: Cancer-programmed cell death

Formula: C9D18NO

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773./[3]Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1163(1):214-225./[4]Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22./[5]Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.

CAS Number: 205679-68-1

Molecular Weight: 174.36

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: DNA/RNA Synthesis;Mitochondrial Metabolism;Reactive Oxygen Species

• Artikelnummer: MEXHY-W001187S-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W001187S-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK