Tiagabine-d4 (hydrochloride)

Product Description: Tiagabine-d4 hydrochloride is deuterated labeled Tiagabine hydrochloride (HY-B0696A). Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].

Applications: Neuroscience-Neuromodulation

Formula: C20H22D4ClNO2S2

References: [1]Braestrup C, et al. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54(2):639-47./[2]Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40(3): p. 32-40./[3]Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50(2): p. 365-70./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 416.03

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: GABA Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B0696AS-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0696AS-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK