Tipranavir-d7

Product Description: Tipranavir-d7 is deuterated labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM[1][2]. Tipranavir inhibits SARS-CoV-2 3CLpro activity[3].

Applications: COVID-19-anti-virus

Formula: C32H28D7F3N2O5S

References: [1]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212./[2]Li F, et al. Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos. 2010 May;38(5):871-8./[3]Aoki M, et al. Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1. J Virol. 2012 Dec;86(24):13384-96./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 623.73

Research Area: Infection

Solubility: 10 mM in DMSO

Target: HIV;HIV Protease;Isotope-Labeled Compounds;SARS-CoV

• Artikelnummer: MEXHY-15148S1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15148S1-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK