Trelagliptin-13C,d3, CAS 2707203-34-5

Product Description: Trelagliptin-13C,d3 is a deuterated labeled Trelagliptin[1]. Trelagliptin (SYR-472) is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM. Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM)[2].

Formula: C17 13CH17D3FN5O2

References: [1]Bhumika D Patel, et al. Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors. Eur J Med Chem. 2014 Mar 3;74:574-605./[2]Charles E Grimshaw, et al. Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism. PLoS One. 2016 Jun 21;11(6):e0157509./[3]Shiliang Li, et al. Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes. J Med Chem. 2019 Mar 14;62(5):2348-2361./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

CAS Number: 2707203-34-5

Molecular Weight: 361.39

Research Area: Metabolic Disease

Target: Dipeptidyl Peptidase;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-15408S-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15408S-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK