Venetoclax-d8, CAS 1257051-06-1

Product Description: Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

Applications: Cancer-programmed cell death

Formula: C45H42D8ClN7O7S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Bi C, et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102(4):755-764./[3]Peirs S, et al. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. Blood. 2014 Dec 11;124(25):3738-47./[4]Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8.

CAS Number: 1257051-06-1

Molecular Weight: 876.49

Compound Purity: 99.76

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Autophagy;Bcl-2 Family

• Artikelnummer: MEXHY-15531S-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15531S-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK