Zidovudine-d4

Product Description: Zidovudine-d4 is deuterated labeled Zidovudine (HY-17413). Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Zidovudine increases CRISPR/Cas9-mediated editing frequency.

Applications: COVID-19-anti-virus

Formula: C10H9D4N5O4

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Gray LR, et al. The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes. PLoS One. 2013 Apr 16;8(4):e62196./[3]Mizutani T, et al. Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7122-9./[4]Hou P, et al. Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. Sci Rep. 2015 Oct 20;5:15577.

Molecular Weight: 271.27

Research Area: Cancer; Infection

Solubility: 10 mM in DMSO

Target: CRISPR/Cas9;HIV;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-17413S2-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-17413S2-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK