Bruceine D, CAS 21499-66-1

Formulation: A solid

Formal Name: 13,20-epoxy-1β,11β,12α,14,15β-pentahydroxy-picras-3-ene-2,16-dione

Purity: ≥98%

Formula Markup: C20H26O9

Formula Weight: 410,4

Shelf life (days): 1460

CAS Number: 21499-66-1

Notes: Bruceine D is a quassinoid that has been found in B. javanica and has diverse biological activities.{66657,66658,66659,66660} It is active against chloroquine-resistant P. falciparum (IC50 = 0.015 µg/ml).{66657} Bruceine D selectively inhibits the proliferation of PANC-1, SW 1990, and Capan-1 pancreatic cancer cells over Hs68 fibroblasts (IC50s = 2.53, 5.21, 1.35, and >30 µM, respectively).{66658} It also induces apoptosis in PANC-1 cells. Bruceine D (20 and 40 mg/kg) protects against MPTP-induced motor impairments and dopaminergic neurodegeneration in a mouse model of Parkinson’s disease.{66659} It decreases carrageenan-induced paw inflammation in rats when administered at doses of 0.25 or 1 mg/kg.{66660}

• Artikelnummer: CAY40140-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40140-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK