Formulation: A solid
Formal Name: 1-(4-fluorophenyl)-N-methyl-N-[4-[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
Purity: ≥98%
Formula Markup: C23H20FN5O3S
Formula Weight: 465,5
Shelf life (days): 1460
CAS Number: 1259028-99-3
Notes: BTT3033 is an inhibitor of integrin α2β1 (EC50 = 130 nM in CHO cells expressing the human receptor).{66942} It is 8-fold selective for integrin α2β1 over integrin α1β1, as well as laminin 332, 40 kDa fibronectin, 120 kDa fibronectin, and vitronectin at 130 nM. BTT3033 inhibits the adhesion of platelets in isolated mouse whole blood to collagen I-coated capillaries at a constant shear rate (EC50 = 6 µM). In vivo, BTT3033 (10 mg/kg, p.o.) decreases lavage fluid leukocyte infiltration in a mouse model of platelet-activating factor-induced air pouch inflammation.{66943} It decreases ear thickness in a mouse model of ovalbumin- and alum-induced mouse model of skin hypersensitivity when administered at a dose of 10 mg/kg.
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