Dexmedetomidine, CAS 113775-47-6

Formulation: A solid

Formal Name: 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

Purity: ≥98%

Formula Markup: C13H16N2

Formula Weight: 200,3

Shelf life (days): 1460

CAS Number: 113775-47-6

Notes: Dexmedetomidine is an agonist of α2-adrenergic receptors (α2-ARs).{51154} It selectively binds to α2-ARs over α1-ARs (Kis = 0.015 and 5 nM, respectively). In vivo, dexmedetomidine (50 µg/kg) prevents increases in cardiac troponin I (CTnI), a marker of myocardial injury, as well as reduces myocardial apoptosis, pyroptosis, and ferroptosis in a mouse model of sepsis induced by cecal ligation and puncture (CLP), effects that can be reversed by the α2-AR antagonist yohimbine (Item No. 19869).{66631} Dexmedetomidine (40 µg/kg) induces sedation and decreases mechanical nociception in cats.{66630} Formulations containing dexmedetomidine have been used as sedatives. This product is also available as an analytical reference standard (Item No. 38806).

• Artikelnummer: CAY39544-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39544-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK