Product Description: Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes[1].
Applications: Metabolism-protein/nucleotide metabolism
Formula: N/A
References: [1]Weber BW, et al. The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning. J Biol Chem. 2013 Oct 4;288(40):28514-23./[2]Li W, et al. An Amidase Contributes to Full Virulence of Sclerotinia sclerotiorum. Int J Mol Sci. 2022 Sep 23;23(19):11207./[3]Weber BW,et.al. The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning. J Biol Chem. 2013 Oct 4;288(40):28514-23.
CAS Number: 9012-56-0
Molecular Weight: N/A
Research Area: Metabolic Disease
Solubility: 10 mM in DMSO
Target: Endogenous Metabolite