Citrullinated α-Enolase (human, recombinant)

Formulation: TBS, pH 7.4

Purity: ≥90% estimated by SDS-PAGE

Shelf life (days): 730

Notes: α-Enolase, also known as enolase-1, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate.{42086} It is ubiquitously expressed in human tissues, including liver, spleen, kidney, and brain. In cells, α-enolase is primarily localized to the cytoplasm, however, an alternatively translated form localizes to the nucleus and lacks glycolytic enzyme activity.{42086,42087} α-Enolase functions as a cell surface receptor for plasminogen on pathogens and activated immune cells, as an oxidative stress protein in endothelial cells, and as a chromatin binding partner to facilitate transcription.{42087,42088,42089} It is an autoantigen in asthma, Hashimoto's encephalopathy, and rheumatoid arthritis, and has been found in the serum of pediatric patients with juvenile idiopathic arthritis.{42090,42091,42092,36062} α-Enolase is also subject to citrullination by peptidyl arginine deiminases (PADs) and citrullinated α-enolase has been found in the synovial fluid of rheumatoid arthritis patients.{42092}

• Artikelnummer: CAY21585
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21585-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK