COX-2 (ovine, recombinant)

Purity: ≥80% estimated by SDS-PAGE

Shelf life (days): 180

Notes: Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins.{500,501} The COX component converts arachidonic acid to the hydroperoxy endoperoxide prostaglandin G2 (PGG2; Item No. 17010), and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Item No. 17020). COX2 expression is induced by a variety of stimuli, including phorbol esters, LPS, and cytokines and is responsible for the biosynthesis of PGs under acute inflammatory conditions.{54420,14766} Thus, COX-2 has been the focus of attention for nonsteroidal anti-inflammatory drug (NSAID) development. Cayman’s COX-2 (ovine, recombinant) protein can be used for enzyme activity assays.

• Artikelnummer: CAY18356
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18356-5
• Green Labware: Nein
• Verpackungseinheit: 5 Kunits
• Mengeneinheit: STK