E3 Ligase Ligand 2, CAS 5054-59-1

Formulation: A solid

Formal Name: 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-1H-isoindole-1,3(2H)-dione

Purity: ≥95%

Formula Markup: C13H10N2O5

Formula Weight: 274,2

Shelf life (days): 1460

CAS Number: 5054-59-1

Notes: E3 ligase ligand 2 is an active metabolite of thalidomide (Item No. 14610) and an intermediate in the synthesis of proteolysis-targeting chimeras (PROTACs) containing thalidomide, a ligand for the E3 ubiquitin ligase cereblon (CRBN), used in targeted protein degradation.{65337,65339} E3 ligase ligand 2 is formed from thalidomide via hydroxylation. It decreases the production of TNF-α induced by 12-O-tetradecanoylphorbol 13-acetate (TPA; Item No. 10008014) in THP-1 cells when used at a concentration of 30 µM.{65338} E3 ligase ligand 2 (333 µM) completely inhibits the proliferation of human umbilical vein endothelial cells (HUVECs). It inhibits VEGF- and FGF2-induced angiogenesis by 14% in a chicken chorioallantoic membrane (CAM) assay in utero when administered at a dose of 100 µg/embryo.{65337}

• Artikelnummer: CAY36664-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36664-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK
• Methode: Reinstoffe