Gefitinib-based PROTAC 3, CAS 2230821-27-7

Formulation: A crystalline solid

Formal Name: (2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥98%

Formula Markup: C47H57ClFN7O8S

Formula Weight: 934,5

Shelf life (days): 1460

CAS Number: 2230821-27-7

Notes: Gefitinib-based PROTAC 3 is a proteolysis-targeting chimera (PROTAC) comprised of the EGF receptor (EGFR) inhibitor gefitinib (Item No. 13166) linked to the von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand VHL ligand 1 (Item No. 21591).{52051} In cell-based assays, gefitinib-based PROTAC 3 induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion with half-maximal degradation (DC50) values of 22.3 and 11.7 nM, respectively, but does not induce degradation of wild-type EGFR at concentrations up to 10 μM.

• Artikelnummer: CAY28597-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 28597-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK