GSK3β (human, recombinant)

Formulation: Active recombinant human GST-tagged, His-tagged GSK3β expressed in insect cells

Purity: ≥90% estimated by SDS-PAGE

Shelf life (days): 180

Notes: Glycogen synthase kinase 3β (GSK3β) is a serine/threonine protein kinase that has roles in numerous signaling pathways and cellular processes, including cell proliferation and survival, as well as neural development and plasticity.{60859,60860} It is composed of an N-terminal β-strand domain, a kinase domain, and a C-terminal α-helical domain.{60861} GSK3β is constitutively active, ubiquitously expressed, and localizes predominantly to the cytosol but is also found in the nucleus and mitochondria.{60860,60862} It is inhibited by phosphorylation at serine 9 (Ser9), which is mediated by a variety of kinases, including PKA, PKB, and Akt, and has roles in insulin, growth factor, and Wnt signaling pathways.{60860} GSK3β is involved in several pathophysiological conditions, such as diabetes, cancer, inflammation, and neurological or psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and bipolar disorder.{60862,60859} Cayman's GSK3β (human, recombinant) protein can be used for enzymatic activity assays.

• Artikelnummer: CAY33738
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33738-10
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK
• Wirt: Cell Line