HDAC10 (human, recombinant)

Formulation: 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 0.04% Tween-20, 20% glycerol, and 90 µg/ml DYKDDDDK peptide

Purity: ≥62% estimated by SDS-PAGE

Shelf life (days): 180

Notes: Histone deacetylase 10 (HDAC10) is a zinc-dependent metalloenzyme and class IIb HDAC.{22864} It is composed of an N-terminal catalytic domain and a C-terminal leucine-rich domain. HDAC10 is ubiquitously expressed and shuttles between the cytoplasm and nucleus.{72478} It acts as a transcriptional corepressor and deacetylates histones and polyamines, such as N8-acetylspermidine.{72478,72479} HDAC10 is involved in DNA damage repair, autophagy, and inflammation.{72480} Overexpression of HDAC10 promotes proliferation of lung cancer cells in vitro, and knockout of Hdac10 protects mice against allergic airway inflammation.{72481,72482} SNPs in HDAC10 have been found in patients with schizophrenia.{72483} Cayman’s HDAC10 (human, recombinant) protein has a calculated molecular weight of 67 kDa.

• Artikelnummer: CAY42085-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42085-50
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK
• Klonalität: Recombinant