Irisin (human, recombinant), CAS 9037-90-5

Formulation: 50 mM Tris pH 8.0, 150 mM sodium chloride, and 20% glycerol

Purity: ≥85% estimated by SDS-PAGE

Shelf life (days): 365

CAS Number: 9037-90-5

Notes: Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1α (PGC-1α), regulates mitochondrial biogenesis and function.{21133} Expression of the membrane protein Fibronectin type III domain-containing protein 5 (FNDC5) is stimulated in muscle by PGC-1α in response to exercise. FNDC5 is proteolytically cleaved and secreted as the hormone peptide irisin (named after the Greek goddess messenger Iris). Irisin has been shown to convert white adipose fat to brown adipose fat upon physical exertion. Brown adipose fat allows for mitochondrial uncoupling leading to thermogenetic programs and heat expenditure.{20433} The physiological responses induced by the effects of irisin have the potential to increase weight loss and reduce insulin resistance and obesity.

• Artikelnummer: CAY11451
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11451-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK