JAK1 (human, recombinant)

Formulation: 25 mM Tris-HCl, pH 8.0, with 427 mM NaCl, 1.3 mM KCl, 0.02% Tween 20, 3 mM DTT, 14 mM glutathione, and 50% glycerol

Purity: ≥63% estimated by SDS-PAGE

Shelf life (days): 180

Notes: JAK1 is a non-receptor tyrosine kinase that has roles in immune signaling.{62148,19346,54923} It is composed of N-terminal FERM and SH2 domains, a regulatory pseudokinase domain, and a C-terminal kinase domain.{19346} It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane.{54923} Activation of these cytokine receptors activates JAK1 and induces its dimerization and kinase activity, leading to JAK1 phosphorylation of STAT transcription factors and transcription of immune-related target genes.{19346,62149} JAK1 signaling is inhibited by the suppressor of cytokine signaling (SOCS) proteins SOCS-1, SOCS-3, and SOCS-5.{54924,62152} Knockout of Jak1 in mice results in perinatal mortality and deficits in lymphopoiesis.{62150} JAK1 fusion proteins and activating mutations in JAK1 are associated with acute myeloid leukemia (AML) and T cell precursor acute lymphoblastic leukemia (ALL).{62151} Cayman’s JAK1 (human, recombinant) protein can be used for enzyme activity assays.

• Artikelnummer: CAY33741
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33741-10
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK