Lenalidomide, CAS 191732-72-6

Formulation: A crystalline solid

Formal Name: 3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione

Purity: ≥98%

Formula Markup: C13H13N3O3

Formula Weight: 259,3

Shelf life (days): 1460

CAS Number: 191732-72-6

Notes: Lenalidomide is a derivative of the immunomodulatory compound thalidomide (Item No. 14610).{64871} It reduces TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs) and whole blood stimulated by LPS from S. minnesota (Item No. 23608; IC50s = 13 and 25 nM, respectively). Lenalidomide has been used as a building block in the synthesis of PROTACs that induce the degradation of Ikaros family zinc finger protein 1 (IKZF1) and IKZF3 in MM.1S multiple myeloma cells.{64872} Orally administered lenalidomide (250 mg/kg per day) reduces vascularization and total microvascular length in a rat mesenteric window assay.{64873} Formulations containing lenalidomide have been used in the treatment of myelodysplastic syndrome and multiple myeloma.

• Artikelnummer: CAY14643-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14643-1
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK