Lenalidomide-d5, CAS 1227162-34-6

Formulation: A solid

Formal Name: 5-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione-3,3,4,4,5-d5

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C13H8D5N3O3

Formula Weight: 264,3

Shelf life (days): 1460

CAS Number: 1227162-34-6

Notes: Lenalidomide-d5 is intended for use as an internal standard for the quantification of lenalidomide (Item No. 14643) by GC- or LC-MS. Lenalidomide is a derivative of the immunomodulatory compound thalidomide (Item No. 14610).{64871} It reduces TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs) and whole blood stimulated by LPS from S. minnesota (Item No. 23608; IC50s = 13 and 25 nM, respectively). Lenalidomide has been used as a building block in the synthesis of PROTACs that induce the degradation of Ikaros family zinc finger protein 1 (IKZF1) and IKZF3 in MM.1S multiple myeloma cells.{64872} Orally administered lenalidomide (250 mg/kg per day) reduces vascularization and total microvascular length in a rat mesenteric window assay.{64873} Formulations containing lenalidomide have been used in the treatment of myelodysplastic syndrome and multiple myeloma.

• Artikelnummer: CAY22370-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 22370-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung