Leukotriene A4 Hydrolase (human, recombinant)

Formulation: 100 mM Tris, pH 8.0, with 100 mM potassium chloride and 20% glycerol

Purity: ≥90% estimated by SDS-PAGE

Shelf life (days): 365

Notes: Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that converts LTA4 into LTB4, a potent neutrophil chemoattractant.{12673} In addition to the hydrolase activity, LTA4H also exhibits anion-dependent aminopeptidase activity.{12673,12624} LTA4H is a potential new drug target for a variety of indications associated with leukocyte infiltration to sites of inflammation. Cayman’s LTA4H (human, recombinant) has been expressed and purified from E. coli. Both the epoxide hydrolase and aminopeptidase activities of the enzyme are functional as assessed by measurement of the separate enzyme activities. The enzyme therefore has application for the screening of inhibitors of LTB4 synthesis.

• Artikelnummer: CAY10007817
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10007817-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: Western Blotting