MZ1, CAS 1797406-69-9

Formulation: A crystalline solid

Formal Name: (4R)-N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide

Purity: ≥98%

Formula Markup: C49H60ClN9O8S2

Formula Weight: 1002,6

Shelf life (days): 1460

CAS Number: 1797406-69-9

Notes: MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4).{33482} It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 µM.{33482} At concentrations of 2-10 µM, MZ1 causes the removal of BRD2, BRD3, and BRD4.{33482} BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.{33482}

• Artikelnummer: CAY21622-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21622-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK