PRMT6 (human recombinant; baculovirus expressed)

Formulation: 50 mM Tris-HCl, pH 8.0, with 150 mM sodium chloride and 20% glycerol

Purity: ≥60%

Shelf life (days): 365

Notes: Protein arginine methyltransferases (PRMTs) are a family of enzymes with highly conserved catalytic domains that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to a specific arginine residue in a target protein. PRMT6 is a nuclear type-1 PRMT, catalyzing the formation of ω-NG-monomethylarginine and asymmetric ω-NG,NG-dimethylarginine on both histone and non-histone targets.{20285,20245,20284} Histone H3 methylation of arginine 2 (H3R2) is a repressive transcriptional mark primarily catalyzed by PRMT6.{20286} H3R2 dimethylation antagonizes the binding of effector proteins sensitive to H3K4 methylation, such as the Mixed Lineage Leukemia complex methyltransferase.{20287} Non-histone targets of PRMT6 include the nuclear high-mobility group protein HMGA1a, a protein important in several processes relating to the maintenance of DNA integrity.{20284}

• Artikelnummer: CAY13866
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13866-50
• Green Labware: Nein
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK