SET7/9 (human recombinant)

Formulation: 50 mM HEPES, pH 7.2, 100 mM sodium chloride, and 20% glycerol

Purity: ≥95% estimated by SDS-PAGE

Shelf life (days): 180

Notes: Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function.{17223} Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase.{17224} SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10.{16846} Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation.{17223} SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.

• Artikelnummer: CAY10320
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10320-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK