SIRT7 (human, recombinant)

Formulation: 50 mM NaPO4, pH 7.2, with 100 mM NaCl and 20% glycerol

Purity: ≥35% estimated by SDS-PAGE

Shelf life (days): 365

Notes: The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group.{15271,15275,15273} There are seven human sirtuins, which have been designated SIRT1-SIRT7.{15274} SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53.{17220} SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.{17219}

• Artikelnummer: CAY10316
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10316-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: Western Blotting