TYK2 JH2 Domain (human, recombinant; aa 575-869)

Formulation: 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 0.04% polysorbate 20, 20% glycerol, and 3 mM DTT

Purity: ≥84% estimated by SDS-PAGE

Formula Weight: 0

Shelf life (days): 180

Notes: Tyrosine kinase 2 (TYK2) is a member of the JAK family of non-receptor tyrosine kinases that has a key role in cytokine signaling.{62097,62098} It is composed of an N-terminal FERM homology domain, which mediates protein-protein interactions, a Src-homology 2 (SH2) domain, an autoinhibitory and catalytically inactive pseudokinase domain (JH2), and a C-terminal kinase domain.{62097} TYK2 is expressed by a variety of immune cells, including T cells, B cells, dendritic cells, mast cells, and macrophages, where it associates with numerous cytokine receptor chains, including IFN-α/β receptor 1 (IFNAR1), IL-12Rβ1, IL-10R2, glycoprotein 130 (gp130), and IL-13Rα1, to mediate STAT-dependent cytokine signaling.{62098,62097,62099} TYK2 is activated by its phosphorylation, which is induced by ligand-bound cytokine receptors via JAK1 or JAK2-mediated transactivation, and is inhibited by suppressor of cytokine signaling (SOCS) proteins or autoinhibited by the JH2 domain.{62099,62105} TYK2 has roles in numerous immunological processes, including inflammatory and autoimmune diseases, pathogen defense, and allergy, as well as tumor surveillance and cancer.{62097,62099} TYK2 containing an isoleucine-to-serine substitution (TYK2I684S) in the JH2 domain has reduced activity but restores cytokine-induced signaling when expressed in TYK2-/- U1A cells.{51918} TYK2 SNPs have been identified in patients with acute myeloid leukemia, and TYK2 polymorphisms have been associated with systemic lupus erythematosus (SLE) and multiple sclerosis in humans.{62097} Cayman's TYK2 JH2 Domain (human, recombinant; aa 575-869) protein can be used for binding assays.

• Artikelnummer: CAY42270-20
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42270-20
• Verpackungseinheit: 20 µg
• Mengeneinheit: STK
• Klonalität: Recombinant