9-Aminoacridine, CAS 90-45-9

Product Description: 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections[1][2][3].

Applications: Cancer-programmed cell death

Formula: C13H10N2

References: [1]S Grzesiek, et al. The 'delta pH'-probe 9-aminoacridine: response time, binding behaviour and dimerization at the membrane. Biochim Biophys Acta. 1988 Mar 3;938(3):411-24./[2]Pengfei She, et al. Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumonia. Microbiol Spectr. 2023 Jun 15;11(3):e0447422./[3]Irene Guendel, et al. 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. Virol J. 2009 Jul 24:6:114.

CAS Number: 90-45-9

Molecular Weight: 194.23

Compound Purity: 99.50

Research Area: Infection

Solubility: DMSO : 27.5 mg/mL (ultrasonic)

Target: Bacterial;HIV

• Artikelnummer: MEXHY-B1422-250
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1422-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK