Ac-DEVD-AMC, CAS 169332-61-0

Product Description: Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm[1][2][3].

Applications: Cancer-programmed cell death

Formula: C30H37N5O13

References: [1]Nobel CS, et al. Disulfiram is a potent inhibitor of proteases of the caspase family. Chem Res Toxicol. 1997 Dec;10(12):1319-24. /[2]Ochu EE, et al. Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. J Neurochem. 1998 Jun;70(6):2637-40. /[3]Yakovlev AA, Gorokhovatsky AY, Onufriev MV, Beletsky IP, Gulyaeva NV. Brain cathepsin B cleaves a caspase substrate. Biochemistry (Mosc). 2008 Mar;73(3):332-6.

CAS Number: 169332-61-0

Molecular Weight: 675.64

Compound Purity: 99.93

Research Area: Others

Solubility: H2O : < 0.1 mg/mL

Target: Fluorescent Dye

• Artikelnummer: MEXHY-P1003-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P1003-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK