Aclacinomycin A, CAS 57576-44-0

Product Description: Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis[1][2][3].

Applications: Cancer-Kinase/protease

Formula: C42H53NO15

References: [1]Isoe T, et al. Inhibition of different steps of the ubiquitin system by CDDP and aclarubicin. Biochim Biophys Acta. 1992 Sep 15;1117(2):131-5./[2]Hajji N, et al. Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor. Mutat Res. 2005 May 2;583(1):26-35./[3]Iihoshi H, et al. Aclarubicin, an anthracycline anti-cancer drug, fluorescently contrasts mitochondria and reduces the oxygen consumption rate in living human cells. Toxicol Lett. 2017 Aug 5;277:109-114. /[4]Hori S, Shirai M, Hirano S, Oki T, Inui T, Tsukagoshi S, Ishizuka M, Takeuchi T, Umezawa H. Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity. Gan. 1977 Oct;68(5):685-90.

CAS Number: 57576-44-0

Molecular Weight: 811.87

Compound Purity: 98.95

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Antibiotic;DNA/RNA Synthesis;Proteasome;Topoisomerase

• Artikelnummer: MEXHY-N2306-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N2306-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK