Dansylcadaverine, CAS 10121-91-2

Product Description: Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands[1][2].

Formula: C17H25N3O2S

References: [1]Huff T, et al. Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescentdansylcadaverine does not abolish interaction with G-actin. FEBS Lett. 1999 Dec 24;464(1-2):14-20./[2]Laha D, et al. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7. Biochim Biophys Acta. 2014 Jan;1840(1):1-9./[3]Gao L, et al. Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis. J Mol Med (Berl). 2018;96(9):929-938./[4]Cornwell MM, et al. Inhibition of the adhesion of Chinese hamster ovary cells by the naphthylsulfonamides dansylcadaverine and N-(6-aminohexyl)-5-chloro-1-naphthylenesulfonamide (W7). Biochim Biophys Acta. 1983;762(3):414-419./[5]David SA, et al. Analysis of the binding of polymyxin B to endotoxic lipid A and core glycolipid using a fluorescent displacement probe. Biochim Biophys Acta. 1992;1165(2):147-152.

CAS Number: 10121-91-2

Molecular Weight: 335.46

Compound Purity: 98.62

Research Area: Others

Solubility: DMSO : 62.5 mg/mL (ultrasonic)/H2O : 1 mg/mL (ultrasonic;warming;heat to 80°C)

Target: Autophagy

• Artikelnummer: MEXHY-D1027-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-D1027-10.1
• Green Labware: Nein
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK