DIDS (sodium salt), CAS 67483-13-0

Product Description: DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research[1][2][3][4].

Formula: C16H8N2Na2O6S4

Citations: Adv Sci (Weinh). 2021 Nov;8(21):e2101936./Autophagy. 2021 Nov;17(11):3592-3606./Biochem Biophys Res Commun. 2021 May./bioRxiv. 2023 Jul 3./Cancer Sci. 2020 Nov;111(11):4288-4302./FEBS Open Bio. 2021 Dec 30./J Cell Mol Med. 2021 May 5./Life Sci. 2020 Oct 15;259:118390./SSRN. 2023 Nov 14./Cell Death Discov. 2023 Jul 8;9(1):234.

References: [1]Tsou CY, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810./[2]Chen H, et al. Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. Apoptosis. 2014 Dec;19(12):1712-26.

CAS Number: 67483-13-0

Molecular Weight: 498.48

Compound Purity: 99.13

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)/H2O : 33.33 mg/mL (ultrasonic)

Target: RAD51;VDAC

• Artikelnummer: MEXHY-D0086-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-D0086-10.1
• Green Labware: Nein
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK