Direct Blue 1, CAS 2610-05-1

Product Description: Direct Blue 1 (Chicago Sky Blue 6B) is a complex dye for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1 is a potent and competitive VGLUT inhibitor. Direct Blue 1 can inhibit the Aβ-binding small molecule PrP ligand. Direct Blue 1 has anti-inflammatory activity[1][2][3][4][5][6].

Formula: C34H24N6Na4O16S4

References: [1]Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015;60(4):340-344./[2]Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013;24(8):653-658./[3]Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015;290(27):17020-17028./[4]Min JO, et al. Chicago sky blue 6B inhibits α-synuclein aggregation and propagation. Mol Brain. 2022 Mar 28;15(1):27./[5]Jin K, et al. Chicago sky blue 6B (CSB6B), an allosteric inhibitor of macrophage migration inhibitory factor (MIF), suppresses osteoclastogenesis and promotes osteogenesis through the inhibition of the NF-κB signaling pathway. Biochem Pharmacol. 2021 Oct;192:114734./[6]He Z, et al. Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice. Behav Brain Res. 2013 Feb 15;239:172-6.

CAS Number: 2610-05-1

Molecular Weight: 992.80

Compound Purity: 95.0

Research Area: Inflammation/Immunology

Solubility: DMSO : 125 mg/mL (ultrasonic)/H2O : 2.08 mg/mL (ultrasonic)

Target: Amyloid-β;NF-κB

• Artikelnummer: MEXHY-D0939-500
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-D0939-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK