JC-1, CAS 3520-43-2

Product Description: JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells, tissues or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585nm, Em=590nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=514nm, em=529nm)[1].

Formula: C25H27Cl4IN4

References: [1]Jung-Ho LEE, et al. Real-time analysis of amyloid fibril formation of α-synuclein using a fibrillation-state-specific fluorescent probe of JC-1. Biochem. J. 2009, 418:311-323./[2]A Perelman, et al. JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry. Cell Death Dis. 2012 Nov 22;3:e430./[3]Vera C. Keil, et al. Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria. Pflügers Archiv - European Journal of Physiology. 2011,462(5): 693-708./[4]Salvioli S, et al. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett. 1997 Jul 7;411(1):77-82.

CAS Number: 3520-43-2

Molecular Weight: 652.23

Compound Purity: 99.0

Research Area: Others

Solubility: DMSO : 5 mg/mL (ultrasonic;warming)/H2O : < 0.1 mg/mL

Target: Fluorescent Dye

• Artikelnummer: MEXHY-15534-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15534-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK