Fluorofenidone, CAS 848353-85-5

Formulation: A solid

Formal Name: 1-(3-fluorophenyl)-5-methyl-2(1H)-pyridinone

Purity: ≥98%

Formula Markup: C12H10FNO

Formula Weight: 203,2

Shelf life (days): 1460

CAS Number: 848353-85-5

Notes: Fluorofenidone is an antifibrotic agent and a derivative of pirfenidone (Item No. 13986).{72243,72244} It inhibits angiotensin II-induced increases in TGF-β1 secretion and reactive oxygen species (ROS) production, as well as TGF-β1-induced production of collagen I, in NRK-52E rat proximal tubular epithelial cells when used at a concentration of 8 mM.{72243} Fluorofenidone (500 mg/kg) decreases disease severity and the renal levels of collagen I, collagen III, and connective tissue growth factor (CTGF) in a rat model of obstructive nephropathy induced by unilateral ureteral obstruction.{72244} Fluorofenidone also increases survival in a mouse model of LPS-induced endotoxemia when administered at a dose of 200 mg/kg.{72245}

• Artikelnummer: CAY39651-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39651-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK