GP 2a, CAS 919077-81-9

Formulation: A solid

Formal Name: N-cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methyl-indeno[1,2-c]pyrazole-3-carboxamide

Purity: ≥98%

Formula Markup: C24H23Cl2N3O

Formula Weight: 440,4

Shelf life (days): 1460

CAS Number: 919077-81-9

Notes: GP 2a is a cannabinoid 2 (CB2) receptor agonist (Ki = 7.6 nM for the mouse receptor).{67742} It is selective for CB2 receptors over CB1 receptors (Ki = 900 nM for the mouse receptor). GP 2a (5 to 100 nM) induces the CB2 receptor-dependent phosphorylation of ERK1/2 in HL-60 leukemia promyeloblasts. In vivo, GP 2a (4 mg/kg per day) increases the mechanical threshold force to paw withdrawal and the latency to paw withdrawal from a radiant heat stimulus in a mouse model of neuropathic pain induced by spared nerve injury (SNI).{67743} GP 2a inhibits SNI-induced increases in the number of activated spinal microglia and spinal astrocytes in the same mice.

• Artikelnummer: CAY40761-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40761-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK